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--- sjogren_syndrome [2023/03/07 14:10] – Scott Larson
+++ sjogren_syndrome [2026/07/28 12:24] (current) – [Diagnostic Criteria 2016] Scott Larson
@@ Line 6: / Line 6: @@
   * Other autoimmune diseases: Rheumatoid Arthritis, Systemic Lupus Erythematosis, Scleroderma, Undifferentiated connective tissue disease, Reynaud, Hashimoto, Chron's Disease
   * Family History of autoimmune diseases
-  * Schirmer test (unanesthetized) ≤ 5mm in 5 minutes
+  * [[schirmer_test|Schirmer test]] (unanesthetized) ≤ 5mm in 5 minutes
   * Ocular Surface Staining
-    * OSS > 3-5
+    * [[ocular_surface_staining_score|OSS > 3-5]]
     * Conjunctival lissamine green staining
 ===== Diagnostic Criteria 2016 =====
+<WRAP round box 80%>
 |Item|Weight/Score|
 |Anti-SSA / Ro antibody positivity|3|
-|Focal lymphocytic sialadenitis with a focus score of ≥ 1 foci / 4 mm²|3|
+|Focal lymphocytic sialadenitis* with a focus score of ≥ 1 foci / 4 mm²|3|
 |Abnormal ocular staining score of ≥ 5 (or van Bijsterveld score of ≥ 4) |1|
 |Shirmer's test (no local anesthetic) result of ≤ 5mm / 5 minutes|1|
 |Unstimulated salivary flow rate of ≤ 0.1 ml/minute|1|
+*A histological feature defined by tightly-aggregated mononuclear cells adjacent to striated ducts
 Source: {{ ::shiboski_-_2016_american_college_of_rheumatology_european_league_against_rheumatism.pdf |Shiboski et. al. 2016 American College of Rheumatology Classification Criteria for Primary Sjögren's Syndrome}}
+</WRAP>
 {{tag>syndrome}}

syndrome