Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revision Previous revision
Next revision		 Previous revision
tag:drugs [2021/04/05 03:08] – Scott Larsontag:drugs [2021/04/05 03:17] (current) – removed Scott Larson
Line 1: Line 1:
-====== Ivacaftor ====== 
-AKA Orkambi (lumacaftor/ivacaftor) 
- 
-  * Drug used in the treatment of Cystic Fibrosis 
-  * transmembrane conductance regulator potentiator  
-  * Approved for ages 2 and older 
-  * [[https://www-bmj-com.proxy.lib.uiowa.edu/content/361/bmj.k1783|Review Article]] 
- 
-==== Cataracts with Ivacaftor ==== 
-  * Cataracts were found in juvenile rats in pre-clinical toxicology studies 
-  * Cataracts have been discovered in a few children taking this drug. The concomitant use of steroids or other pre-existing coniditions could not be excluded.  
-    * [[https://www.atsjournals.org/doi/10.1164/rccm.201608-1754OC#_i11|Lumacaftor/Ivacaftor in Patients Aged 6–11 Years with Cystic Fibrosis and Homozygous for F508del-CFTR]] 
-    * [[https://adc-bmj-com.proxy.lib.uiowa.edu/content/103/1/68|The impact of 12 months treatment with ivacaftor on Scottish paediatric patients with cystic fibrosis with the G551D mutation: a review]] 
-  * Drug manufacturer recommends baseline and follow-up eye examinations of unspecified interval or duration  
-    * [[https://pi.vrtx.com/files/uspi_lumacaftor_ivacaftor.pdf|Prescribing Information]] 
- 
-{{tag>drugs cataract}}