Drugs for Cystic Fibrosis
- Trikafta (elexacaftor/tezacaftor/ivacaftor),
- Kalydeco (ivacaftor)
- Orkambi (lumacaftor/ivacaftor)
- Symdeko (tezacaftor/ivacaftor)
- Alyftrek (vanzacaftor/tezacaftor/deutivacaftor)
- Outside North America, Trikafta is marketed as Kaftrio, and Symdeko as Symkevi
- this class of drugs regular transmembrane conductance
Cataracts with Lumacaftor/Ivacaftor (Orkambi)
- Cataracts were found in juvenile rats in pre-clinical toxicology studies
- Cataracts have been discovered in a few children taking this drug. The concomitant use of steroids or other pre-existing coniditions could not be excluded.
- Drug manufacturer recommends baseline and follow-up eye examinations of unspecified interval or duration
Ocular Complications of Elexacaftor/Tezacaftor/Ivacaftor (Trikafta)
Cataracts / Lens Opacities
- Non-congenital lens opacities have been reported in pediatric patients on ivacaftor-containing regimens. Confounders (corticosteroid use, radiation exposure) were present in some cases, but a drug-attributable risk cannot be excluded.[1]
- Signal originates from juvenile animal toxicology: cataracts occurred in rats dosed from postnatal day 7 through 35 at ivacaftor >=10 mg/kg/day (0.21x MRHD by systemic exposure); not seen in older animals.[1]
- In clinical trials, cataracts are classified as an uncommon adverse event across all CFTR modulators, including ETI, and were not observed as a treatment effect in human trials.[2][3]
Intracranial Hypertension
- Reported postmarketing; manifestations include headache, blurred vision, diplopia, and potential vision loss, with papilledema on fundoscopy.[1]
- Patients with elevated vitamin A levels may be at increased risk — relevant given routine fat-soluble vitamin supplementation in CF.[1]
- If unusual headache or visual disturbance occurs and IH is suspected, interrupt Trikafta and refer for prompt medical evaluation; monitor until resolution and for recurrence. Resumption requires individualized risk-benefit assessment.[1]
Other Reported Ocular Symptoms
In a single-center survey after ETI initiation, ophthalmic complaints were the most frequently reported “other” side effect (7.6%), including cataracts (2.2%), blurred vision (2.2%), and epiphora (1.1%).[4]
Practical Monitoring Approach
| Element | Recommendation |
|---|---|
| Baseline eye exam | Recommended in pediatric patients before/at initiation of ETI |
| Follow-up exams | Follow-up ophthalmologic examinations recommended in pediatric patients; yearly exams most common |
| Adults | No routine screening exam mandated by label; evaluate symptom-driven |
| New headache or visual disturbance (any age) | Interrupt drug; urgent evaluation including fundoscopy for papilledema; consider vitamin A level |
| Class effect | Same cataract monitoring applies to ivacaftor, lumacaftor-ivacaftor, and tezacaftor-ivacaftor |
The recommended exam should include slit-lamp assessment for lens opacities and fundoscopy. The label does not specify a fixed interval beyond “baseline and follow-up”; annual examination during childhood is the convention derived from review guidance.[3]